Periodic Validation of High Antidiabetic Potentials of Unripe Plantain in Comparison with Glibenclamide and Fansidar

Abstract

Problem statement: The antidiabetic potentials of aqueous extract of musa paradisciaca (unripe plantain fruit) were investigated in alloxan induced diabetic rats. The extract at a dosage of 120 mg kg^-1 produced a significant (p<0.001) reduction in glucose level by 85% on day 7, 78% on day 14, 64% on day 21 and 44% on day 28. Approach: The extract at the dosage of 80 mg kg^-1 produced a significant (p<0.01) reduction in glucose concentration by 86% on day 7, 79% on day 14 64%, day 21 and 458% on day 28. With 40 mg kg^-1 glucose level was 83% on day 7, 75% on day 14, 68%, day 21 and 58, 64% on day 21 and 58% on day 28. Results: Fansidar at the calculated average animal dosage 9-22.5 mg kg^-1 from that of man produced a significant (p<0.01) reduction in glucose concentration by 81% on day 7 71% on day 14, 58% on day 21 and on day 28 a shooting to 111%. Comparing the fasting blood glucose levels of extract and fansidar with known antidiabetic drug; Gliben clamide of 6.75 mg kg^-1 had the following on day 7; it was 96, 86% on day 14, 45% on day 21 and 81% on day 28. Conclusion: It is concluded that extract of unripe plantain fruit showed high antidiabetic properties than glibenclamide a known potent antidiabetic drug and fansidar is also demonstrated a good degree of antidabetic potentials.