Research Article Open Access

Patterns of Resection among Patients with Hepatic-Only Metastatic Colorectal Cancer a Single Institution Experience and Review

K.I. Quintyne1, N. O’Leary1, O. O’Kelly1, D. Waldron2, R. Keane2, J. Geoghegan3, B. Kenny2 and R.K. Gupta4
  • 1 Mid-Western Cancer Centre, Ireland
  • 2 Mid-Western Regional Hospital, Ireland
  • 3 St. Vincent’s University Hospital, Ireland
  • 4 University of Limerick, Ireland

Abstract

Problem statement: Hepatic-only metastasis in colorectal cancer is not a rare clinical finding and can account for 30% of cases. However, only 10-25% of cases are suitable for hepatic resection as part of their treatment pathway. We sought to document our own findings by reviewing patients with hepatic-only disease. Approach: A retrospective analysis was designed to include all patients seen at our institution from 1st January 2000 until 30th June 2010 and information as derived from the patients’ records. Results: Forty-four (44) patients were found, with an average age of 60.8 years and a male preponderance. The majority of patients (approximately 57%) with hepatic-only metastases developed their disease following adjuvant therapy. Better overall survival was seen when a primary tumor had a low grade of histological differentiation and fewer than 3 hepatic lesions appreciated on conventional radiology. Better outcome was seen in patients who underwent hepatic resection. Conclusion: Patients with hepatic-only metastases are not uncommon within our institution. Hepatic resection afforded better outcome and compares favorably with published literature.

American Journal of Immunology
Volume 8 No. 1, 2012, 18-26

DOI: https://doi.org/10.3844/ajisp.2012.18.26

Submitted On: 1 April 2012 Published On: 5 April 2012

How to Cite: Quintyne, K., O’Leary, N., O’Kelly, O., Waldron, D., Keane, R., Geoghegan, J., Kenny, B. & Gupta, R. (2012). Patterns of Resection among Patients with Hepatic-Only Metastatic Colorectal Cancer a Single Institution Experience and Review. American Journal of Immunology, 8(1), 18-26. https://doi.org/10.3844/ajisp.2012.18.26

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Keywords

  • Hepatic-only metastatic colorectal cancer
  • hepatic resection
  • chemotherapy
  • hepatic resection
  • colorectal cancer
  • male preponderance
  • majority of patients
  • retrospective analysis