Research Article Open Access

Anti-Prm Antibody as an Autoantibody in Dengue Virus Infection

Kao-Jean Huang1, Yu-Tien Cheng1, Yee-Shin Lin1, Jyh-Hsiung Huang2, Hsiao-Sheng Liu1, Trai-Ming Yeh1, Ching-Chuan Liu1 and Huan-Yao Lei1
  • 1 National Cheng Kung University, Taiwan
  • 2 Center for Disease Control, China

Abstract

We have reported that anti-prM antibody is an enhancing antibody that enhances DV infection of non-Fc receptor bearing cells by dual specificity. We identified the epitope recognized by this anti-prM antibody, M3, which is located at the a.a.53-67of the prM protein nearby the prM/M cleavage junction and these anti-M3 antibodies could be detected in dengue patients sera. Surprisingly, this anti-prM antibody not only recognizes the prM protein of dengue virions, but also cross-reacts with epithelial cells, endothelial cells as well as T cells. The binding of anti-prM antibody to endothelial cells was dose-dependent and could be blocked by M3 peptides. Human M3-specific antibodies from dengue patient sera were demonstrated to be able to bind to endothelial cells and mediate ADE infection on K562 cells. Furthermore, the anti-prM antibody will mediate the antibody - dependent cell phagocytosis, leading to the similar severe form of DHF/DSS. In conclusion, anti-prM antibody plays two roles in the pathogenesis of dengue virus infection: to be an enhancing antibody and an autoantibody as well.

American Journal of Infectious Diseases
Volume 4 No. 1, 2008, 60-68

DOI: https://doi.org/10.3844/ajidsp.2008.60.68

Submitted On: 9 August 2007 Published On: 31 March 2008

How to Cite: Huang, K., Cheng, Y., Lin, Y., Huang, J., Liu, H., Yeh, T., Liu, C. & Lei, H. (2008). Anti-Prm Antibody as an Autoantibody in Dengue Virus Infection. American Journal of Infectious Diseases, 4(1), 60-68. https://doi.org/10.3844/ajidsp.2008.60.68

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Keywords

  • Autoimmunity
  • molecular mimicry
  • antibody
  • virology
  • endothelial cell